11 Jan 2016 Patients · %ROMA = exp(PI)/[1-exp(PI)]*100, · PI = A + W(HE4)*ln(HE4) + W( CA125)*ln (CA125), · Below 20 years old: A = −12; W(HE4) = 2.38; W( 

MDCalc loves calculator creators – researchers who, through intelligent and often complex methods, discover tools that describe scientific facts that can then be applied in practice. These are real scientific discoveries about the nature of the human body, which can …

Chinese Maternal and Child Health. 2017:48–50. 5. Yang S, Lu W, Zheng Y, et al. Analysis of the diagnosis of ovarian cancer by serum CA125, HE4 combined ROMA index.

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CA 125, HE4, and ROMA exhibiting maximum Youden index were de-termined, respectively, as the optimal cutoffs, and sensitivity and specificity were evaluated by applying those cutoffs. Results: In benign diseases, CA 125 significantly increased in patients with uterine myoma, adenomyosis, endometrial pathology, or endometriosis, but HE4 only in- The ROMA® Calculation Tool has been validated only with HE4 and CA 125 results produced with assays from specific manufacturers. The ROMA performed by LabCorp employs the Roche Elecsys HE4 and CA 125 assays as specifically indicated in the FDA-cleared manufacturer’s package insert. References: 1. The combination of CA 125™ + HE4 tests from Fujirebio Diagnostics, Inc., helps ovarian cancer patients find the right doctor for the most optimal outcome. Explore more about ovarian cancer, the new CA 125 + HE4 test, and how this test will help steer patients down the right treatment path.

Figure 1. The receiver operating characteristic of risk of ovarian malignancy algorithm (ROMA) index, human epididymis secretory protein 4 (HE4) and carbohydrate antigen-125 (CA-125) in the diagnosis of ovarian cancer. - "The diagnostic value of serum HE4 and CA-125 and ROMA index in ovarian cancer"

Tumor marker sensitivity in ovarian cancer was 78% for HE4, 63% for CA125, and 88% for ROMA index at 95% specificity. At all women were measured CA 125, HE4 and FSH. HE4 and CA125 were determined using the chemiluminescent device Architect 1000 (Abbott, USA), FSH chemiluminescent method on the device DXI 800 (Beckman Coulter, USA). At all premenopausal women was calculated ROMA1 index and at all postmenopausal women ROMA2 index. 2019-04-01 · Those data suggest that CA-125 and HE4 serum levels, and ROMA were increased with the development of ovarian cancer.

28 Mar 2019 Carbohydrate antigen 125 (CA125) is a traditional marker for ovarian based on the results of serum HE4 and CA125, combined with the calculation of The ROMA index combined serum CA125 HE4 and menopausal state .

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Osjetljivost za karcinom endometrija 1. stupnja za specifičnost 95 % MARKER CA 125 - 15 % HE4 - 54 %. Kod sumnje na karcinom jajnika preporučamo istovremeno određivanje razine CA 125 i HE 4 jer se time dobiva još veća točnost i specifičnost mjerenja, te se može odrediti i ROMA index Objectives . To evaluate the diagnostic performance among CA-125, RMI, HE4, and ROMA for cancer detection in women with nonfunctional ovarian cysts at King Chulalongkorn Memorial Hospital (KCMH). Secondary objective is to reconsider the proper cutoff value of HE4. Methods .
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ca-125 mesothelin antigen retrieval 2017-08-01 · The serum CA 125, HE4 and ROMA concentrations according to histology are provided in detail in Table 2. The CA 125, HE4 and ROMA indices for benign cases versus all malignant diseases or EOC plus LMP tumors alone were significantly different in both the premenopausal and postmenopausal groups (all P < 0.001).

Comparison of HE4, CA125 and ROMA algorithm in women with a pelvic mass: correlation with pathological outcome. The risk of ovarian malignancy algorithm (ROMA) incorporates cancer antigen 125 (CA125), human epididymal protein 4 (HE4), and menopausal status to assign women that present with an adnexal mass into a high-risk or low-risk group for finding an ovarian malignancy. Serum HE4 and CA-125 reference range was <140 pmol/l and <35 U/ml, respectively. ROMA index calculation.
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Evaluation of HE4, CA125, risk of ovarian malignancy algorithm (ROMA) and risk of malignancy index (RMI) as diagnostic tools of epithelial ovarian cancer in patients with a pelvic mass. Gynecologic Oncology , 127 (2), 379-83.

HE4 est une protéine surexprimée chez les patientes ayant un cancer de l'ovaire, même dans les premiers stades (I et II) du cancer, principalement dans les cancers de type séreux. Son expression est indépendante de celle du CA125, et effective dans 50% des cancers qui n'expriment pas le CA125. 2. Karlsen MA, Sandhu N, Hogdall C, et al: Evaluation of HE4, CA125, risk of ovarian malignancy algorithm (ROMA) and risk of malignancy index (RMI) as diagnostic tools of epithelial ovarian cancer in patients with a pelvic mass. Gynecol Oncol. 2012;127(2):379-383 2011-08-31 · ROMA (HE4 EIA + ARCHITECT CA 125 11)DigotcI. Intended Use For In Vitro Diagnostic Use Only.

Diagnostic value of HE4, CA125, ROMA INDEX and ultrasound findings in epithelial ovarian cancer October 2015 Conference: 19th International Meeting of the European Society of Gynaecological

Both tumour markers, HE4 and CA 125 were related to tumour stage and histological type, with the 3.1 CA125, HE4, and the ROMA index values during different trimesters of pregnancy. In this study, we measured serum HE4 and CA125 concentrations in 1006 pregnant women. The results of Kolmogorov‐Smirnov test showed that HE4, CA125, and ROMA index values in our study were not in normal distribution. It is important to note that so far FDA has granted clearance only to the combination of Fujirebio's HE4 assay and Abbott's ARCHITECT CA125 II assay for calculating ROMA scores. Laboratories that want to use a combination of assays from other manufacturers need to establish appropriate cutoff values after conducting their own validations. Distinguishing between malignant and benign ovarian masses is necessary to refer patients to centers with experience in the surgical.The aim of this study was to analyze the diagnostic value of the tumor markers, including risk of malignancy index (RMI), human epididymis protein 4 (HE4), cancer antigen125 (CA125), and risk of ovarian malignancy algorithm (ROMA) in ovarian mass.One hundred Na základě výpočtu ROMA score (Risk of Ovarian Malignancy Algorithm) zahrnující koncentrace CA 125 a HE4 lze odhadnout riziko epitelového karcinomu ovária. Hodnota ROMA score v procentech udává pravděpodobnost přítomnosti epitelového karcinomu ovária, pokud je u pacientky zobrazovací metodou zachycena abnormalita v oblasti ovárií.

3) The diagnostic value of serum HE4 and CA-125 and ROMA index in ovarian cancer. Biomed Rep. 2016 Jul; 5(1): 41–44. 4) Mayo Clinic Laboratories. ROMA Score (Ovarian Malignancy Risk Algorithm), Serum. 자료 녹십자의료재단 전문의 이상곤, 최리화 (Tel 031-260--9209) Electrochemiluminescence immunoassay CA-125 - 53,22 , HE4 -63 wartosc po menopauzie ROMA wynosi 29,49Jeśli u kobiety przed menopauzą test ROMA da wynik poniżej 11,4% - oznacza to niskie ryzyko choroby nowotworowej. Wynik Ginekologia Figure 1.